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The effect of tirzepatide treatment on cardiovascular risk factors and cardiovascular outcomes is being evaluated in the ongoing phase 3 study SURPASS-CVOT (NCT04255433)

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This is generally a transient effect that improves as your body adjusts to the medication

Inform patients to resume their regular once-weekly dosing schedule [see Dosage and Administration ( 2.4 )]

A Phase 2 Randomized Dose-Finding Study of the Novel Once-Weekly Human GLP-1 Analog Semaglutide Compared With Placebo and Open-Label Liraglutide in Patients With Type 2 Diabetes