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10.1159/000527502 102 IepsenE

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Unsuccessful weight loss can also intensify depression symptoms, spike cortisol levels, trigger your fight-or-flight response, and increase cravings for sugary and fatty foods as a result of your body releasing extra blood sugar

[DOI] [PubMed] [Google Scholar] 133.Langlois A, Dal S, Vivot K, Mura C, Seyfritz E, Bietiger W, Dollinger C, Peronet C, Maillard E, Pinget M, Jeandidier N, Sigrist S

Trial participants experienced different levels of % total body weight loss depending on the dose: Percentage of total body weight loss on retatrutide After 48 weeks , 83% of patients taking 12 mg lost at least 15% of their body weight , compared to just 2% of those who were on a placebo

Other medications with some evidence but not FDA approval include certain SSRIs and topiramate