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1 Introduction Since its introduction in 1921, insulin has changed the management and prognosis of patients with type 1 diabetes (T1D)

In vitro activity of GLP-1 analogs in RIN-m5F cells RIN-m5F cells (ATCC, CRL-11605, Manassas, VA, US) were grown in RPMI 1640 (Thermo Fisher Scientific, Boston, MA, US) supplemented with 10% fetal bovine serum (FBS)

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GLP-1 receptor agonists are widely prescribed for diabetes because of their glucose-lowering, weight-reducing and cardiovascular benefits

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Assessing genetic predispositions alongside metabolic markers can help frame a more nuanced clinical conversation: Do genetic markers suggest higher likelihood of glycemic improvement