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Peer-reviewed narrative reviews, systematic reviews, randomized controlled trials, observational studies, and preclinical studies (both in vitro and in vivo) focusing on the pharmacology, pharmacokinetics, safety, drug interactions, toxicology, diabetes, cardiovascular disease, non-alcoholic fatty liver disease, cancer and chemical characterization of BBR were considered eligible

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Indeed, a recent systematic review observed a mean weight loss of 3.1 kg associated with orlistat use [11]