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Plasma Exe4 concentrations in the Donor+Cas9-treated mice remained detectable for over 28 weeks post-injection, indicating continuous secretion achieved through the knock-in approach (Fig

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Pre-existing cardiovascular disease and heart failure were more prevalent among participants in the insulin group (34.6% and 14.8%) than in the other groups (25.6% and 8.7% with GLP-1RA, 23.8% and 7.6% with SGLT2i and 18.9% and 4.9% in the miscellany group, respectively) (Table 1)

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Our biopsychosocial approach predicts that there may be an initial decreased desire from these medications, due to a direct effect on the 5-HT pathway, GI side effects, and other factors compounding an already low baseline sexual desire based on body image

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