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PARP-1, poly (adenosine diphosphate-ribose) polymerase-1

Wiviott SD, Raz I, Bonaca MP et al (2019) Dapagliflozin and cardiovascular outcomes in type 2 diabetes

Warnings regarding the risk of acute pancreatitis are included in the prescribing information for GLP-1 receptor agonists (1318)

The broader benefits beyond glucose control are increasingly recognised in clinical decision-making, though prescribing decisions should be individualised based on patient characteristics, comorbidities, and treatment goals

1) lead to an unparalleled impact on cardio-metabolic pathways by reducing food intake and related reward, increasing satiety, decreasing inflammation and atherogenesis, improving glucose metabolism and storage as well as cardiac, vascular, muscle and adipose tissue function

In the rodent high fat fed male mice model, administration of semaglutide at the dose of 2800 g/kg/day resulted in a significant weight loss attributed to a decreased food intake [70]