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However, GLP-1 RAs significantly increased the change in the 6-min walk test (MWT) distance (MD: 19.74, p = 0.002)

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Results After weighting, 24817 adults used a GLP-1 receptor agonist (mean age 59.9 years

Conclusion GLP-1 RA use was associated with substantially reduced all-cause death but a small increased risk of acute pancreatitis, particularly during early treatment

There are no large trials proving safety, but early data suggests milk transfer is low