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Long-term treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has no effect on beta-amyloid plaque load in two transgenic APP/PS1 mouse models of alzheimers disease

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GLP-1 also suppresses glucagon, a hormone produced by the pancreas that normally raises blood sugar

Thus, using barrier methods could be emphasized because their mechanism of action is not reliant on the gastrointestinal system and therefore are less likely impacted by GLP-1 agonists

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, et al

[DOI] [PubMed] [Google Scholar] 68.Steinberg WM, Nauck MA, Zinman B, Daniels GH, Bergenstal RM, Mann JF, Steen Ravn L, Moses AC, Stockner M, Baeres FM