can you take metformin and semaglutide Wegovy Together? What medication should be discontinued

You should not stop semaglutide without consulting your healthcare provider

Nosemaglutide must be injected into subcutaneous (fatty) tissue to ensure proper absorption and minimize pain

Written May 2026 Reviewed May 2026 Updated May 2026 Read time 21 min All You Need to Know About Semaglutide for Weight Loss Semaglutide is a once-weekly GLP-1 receptor agonist the active ingredient in Wegovy and Ozempic that supports weight loss by mimicking a natural appetite hormone: it reduces hunger, increases fullness and slows digestion, helping you eat less without constant cravings

China-based CDMOs including WuXi STA have also entered the competitive landscape for GMP API supply, leveraging parent company Wuxi AppTec's extensive global regulatory network and established relationships with multinational pharmaceutical company API procurement functions

While one case report showed a significant reduction in pain score following the administration of a thoracic splanchnic nerve block followed by radiofrequency thermocoagulation at the T11 and T12 vertebral levels to target parasympathetic neuropathy in a patient with FD, there are no published data for its use in gastroparesis [147]

Whilst magnesium supplementation is generally considered safe for most individuals, certain circumstances warrant medical consultation before commencing or continuing supplementation, particularly for patients taking GLP-1 medications