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Two practical implications follow

A Mediterranean diet was found to result in higher GLP-1 release than a Western diet (Huber et al 2024)

In addition to local ileal delivery of Ex-9 having no effect on food intake, multiple studies using various peripheral administration routes, including intraperitoneal, jugular venous, and inferior vena cava infusions, showed no effect of GLP-1R antagonism on food intake (86, 87)

(Previously, Ozempic was being used for weight loss but had only been approved for diabetes.) In the years following approval, a growing number of household names from Oprah to Elon Musk spoke publicly about their positive experiences using GLP-1s for weight loss

Glucagon gene 5-flanking sequences direct expression of SV40 large T antigen to the intestine producing carcinoma of the large bowel in transgenic mice