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GLP-1 Receptor Agonists In patients with HFpEF and comorbid obesity or type 2 diabetes mellitus, semaglutide has been incorporated into the 2025 JCS/JHFS heart failure guidelines with a Class IIa recommendation (Level of Evidence B), reflecting moderate-quality evidence supporting improvement in symptoms and functional status

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However, the extent to which these surgical-induced changes in food preference are either directly or indirectly influenced by altered post-surgery ghrelin and/or GLP-1 levels requires future investigation

Physiology of incretins in health and disease

The drugs, approved for conditions including diabetes and obesity, help patients feel fuller faster