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Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years

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Figure 1 4 Clinical evidence of GLP-1R agonists in managing DPN Unlike preclinical evidence, studies investigating the effect of GLP-1R on DPN are quite rare

The FDA-approved prescribing information recommends gradual dose titration over several weeks to minimize these symptoms

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