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So if you or someone you know is on one of these drugs, it's key to maintain muscle mass: lift weights (yes, females too) three times a week heavy and, most importantly, eat enough protein

Calcium is also known to play an important role in neuronal plasticity and neurodegenerative diseases

The SURMOUNT-1 phase 3 double-blind, randomized, controlled trial in adults with obesity without diabetes received once weekly tirzepatide (5, 10, or 15 mg) versus placebo for 72 weeks [9]

However, never alter your dosing schedule without medical guidance, as consistency is important for glycaemic control and weight management outcomes

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On the other hand, the vasodilatory effects of GLP-1 RAs can also be mediated through amelioration of endothelial function, which in turn affects vascular smooth muscle tone through release of nitric oxide, endothelium-derived hyperpolarizing factor, and prostacyclins (Sandoo et al., 2010)