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Its unique mechanism of action, combining GLP-1, GIP and glucagon receptor agonism, has shown impressive weight loss and glycemic control in early phase clinical trials

B., & Nagata, J

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But it is an important consideration, given that the research published so far shows that when patients discontinue using these medications, their appetite returns, and the majority regain some or all of the weight they initially lost
Retatrutide, while showing promising results in early clinical trials including substantial weight loss in Phase 2 studies published in the New England Journal of Medicine remains an investigational medicine
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