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Liu & Borgland, 2015)

GLP-1 Receptor Agonist Market Restraints: High drug costs and manufacturing supply constraints limiting GLP-1 receptor agonist accessibility for patients globally GLP-1 receptor agonists' commercial success has created its own constraint: demand so far exceeds production capacity that patients with legitimate prescriptions cannot reliably obtain their medication

Therefore, recent guidelines recommend GLP-1 RAs for patients with T2DM, established or high-risk atherosclerotic cardiovascular disease, and/or chronic kidney disease for glycemic management and comprehensive cardiovascular risk reduction [6,7]

when drug shortages and high prices have prevented patients from getting highly effective medications that would greatly benefit their health

At the same time, competition among manufacturers and the eventual introduction of new drug classes, including combination and multi-agonist therapies, may affect both pricing and clinical outcomes

Overall, the benefits of finding sustainable ways to reach a healthy bodyweight are far greater than the risk of a few additives and sweeteners