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Its not just a random rule

There are several clinically available drugs that promote browning, but all must be given as pills or injections, says Li Qiang, assistant professor of pathology and cell biology at Columbia University and co-lead author of the study in ACS Nano

Dietary management should follow the principles of nutritional balance, limiting energy intake and adjusting dietary structure

Microdose protocols work best for patients with lower BMI, first-time GLP-1 users, or those titrating upward gradually

The key is timing it away from meals to avoid GI interaction, and not relying on it as a substitute for adequate nutrition and sleep