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The decision to continue, reduce, or stop semaglutide should be made with your healthcare provider based on symptom severity, the benefit you are receiving from the medication, and alternative management options

JAMA 2024;331:38-48

Rather than indicating declining interest, the data suggests the conversation is shifting from viral, event-driven spikes into higher-volume, lower-engagement community discussion

Accessed June 4, 2025.

Declarations Conflict of interest On behalf of all authors, the corresponding author states that there is no conflict of interest

Additionally, intracerebroventricular delivery of Ex-4 has been found to dose-dependently attenuate cue-evoked dopamine activity, further underscoring the direct influence of GLP-1R signaling on neural circuits governing reinforcement and motivation (Konanur et al., 2020)