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[1] The data is clear that these medications do a lot of good

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However, when combined with insulin or sulfonylureas, hypoglycemia risk increases

DPP-4 inhibitors degrade certain entero-hormones (e.g., glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1)), or incretins, which are primarily produced within minutes [9]