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These findings have led to ongoing clinical trials investigating GLP-1-based therapies for alcohol use disorder and other substance use conditions

Managing weight and glycaemic control in patients with both Hashimoto's thyroiditis and type 2 diabetes presents unique challenges, as hypothyroidism itself contributes to weight gain, insulin resistance, and metabolic dysfunction

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Most studies used a placebo as the control treatment, though a few compared GLP-1RAs with other medications or behavioral therapies