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The implication is that there is a neuron population nucleus tractus solitarius GLP-1R neurons that can decrease appetite and cause weight loss without making individuals feel sick and so we hope that this finding will lead to the development of more selective weight loss drugs. We all know that nausea is almost always accompanied by appetite loss, and so we thought that the GLP-1 drugs may suppress appetite simply by making individuals feel nauseated

So far, Novo Nordisk's oral semaglutide and Lilly's orforglipron are available

Originally published in the Spring/Summer 2026 print issue

When given to obese mice, LY3437943 decreased body weight and enhanced glycemic/blood sugar control

Bariatric Surgery-Induced Telogen Effluvium (Bar SITE): Case Report and a Review of Hair Loss Following Weight Loss Surgery