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In an observational study published in 2019, researchers compared Xenical to Saxenda, a type of GLP-1 agonist (2)

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Being a peptide, GLP-1 cannot enter the cell, and thus utilizes a single G protein-coupled receptor (GPCR) residing at the plasma membrane to exert its effects in cells, the GLP-1 receptor (GLP-1R) [6]

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