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Another effect of the whole-body KO of DPP4 in rats is induction of behavioral changes like a blunted stress phenotype (46, 51) and also effects on the immune-regulatory system like blunted NK cell and T-cell function and differential leukocyte subset composition or altered cytokine levels (46, 47)

7.3 From PCOS to endotypes: the role of ML in stratification over promises The diagnostic label of PCOS encompasses a highly heterogeneous pathophysiological spectrum

You may be a candidate for GLP-1 medication if you have a BMI in the overweight or obese range, or if you have a condition called insulin resistance
However, due to the invasive and irreversible nature of weight loss surgeries (with the exception of gastric band surgery), along with the associated risks and the availability of new medication options, surgery is reserved as a final option

Pergolizzi, The Potential Role of Glucagon-Like Peptide-1 (GLP-1) Agonists for Polycystic Ovary Syndrome
These cases were usually linked to severe nausea, vomiting, or diarrhea that led to dehydration and blood flow issues, which can strain the kidneys
