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Additionally, there are important concerns regarding long-term safety

The stimulation of GLP-1 through food is unlikely to achieve the same magnitude of effect as the pharmaceutical drugs, explains Dr Edwards
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The injectable forms of GLP-1 medications deliver nearly 100% of the active compound directly into subcutaneous tissue

In a study published in 2004, Nikolaidis et al

Comparison-adjusted funnel plots did not suggest the presence of small-study effect (ESM Figs 4 and 5)
