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91% reported reduced overall food cravings and helps to maintain a healthy weight

Bonds JA, Shetti A, Stephen TKL, Bonini MG, Minshall RD, Lazarov O

Other important side effects include gallbladder disease (cholelithiasis, cholecystitis), and potential worsening of diabetic retinopathy (particularly with rapid HbA1c reduction on semaglutide)

doi:10.1016/j.ceb.2011.08.004 105

Although the cardioprotective effects of GLP-1RA are more established in atherosclerotic cardiovascular disease than in heart failure, recent studies demonstrate a modest but clinically meaningful benefit in heart failure with preserved ejection fraction (HFpEF), particularly among obese patients

The only literature-reported phase 1 clinical study to date was recently conducted with PF-06882961
