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In 2023, a daily oral orforglipron was found to be associated with weight reduction (9.4% to 14.7%) with similar adverse events when compared to subcutaneous GLP-1R agonists [40]

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These are not published trials

Glucose monitoring results will show the greatest impact of short- and intermediate-acting GLP-1 receptor agonists on postprandial glucose levels

Neuroinflammation in turn, interferes with neuroplasticity by reducing neurogenesis, altering synaptic architecture, and dysregulating neurotransmitter systems [7,8], changes that are closely linked to mood disturbance, cognitive impairment, and affective lability in individuals with IR [4,6,9]

As GLP-1 receptor agonists are increasingly used for weight management and glycemic control, clinicians may consider thyroid dysfunction in the differential diagnosis when relevant symptoms arise during therapy, even in patients without traditional risk factors