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Back in 1965, Samols and his colleagues had helpfully demonstrated that the L-cells reacted with antibodies specific to glucagon which activated the release of insulin (Samols, Marri, Marks, 1965)

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In contrast, the effects of ghrelin on preference for high fat foods are less consistent across studies

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Although all of the above-mentioned studies combined GLP-1 therapy with some form of lifestyle counselling, in each case the latter was described as standardised and infrequent, and can therefore be assumed to have been very much secondary to the medication

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Another possible factor involves increased physical activity

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