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In adults with type 2 diabetes, treatment with tirzepatide 5 mg, 10 mg and 15 mg once weekly was associated with superior weight reduction from baseline compared with placebo, semaglutide 1 mg weekly, titrated insulin degludec, titrated insulin glargine and titrated insulin lispro as an add-on to insulin glargine

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[55] reported that semaglutide treatment caused weight loss and a lesser decrease in energy expenditure as compared with placebo in calorie-restricted, weight-matched rodents