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doi: 10.1016/s0140-6736(65)92278-6

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muciniphila may be present in the oral cavities of healthy individuals but is absent in patients suffering from severe periodontitis [74]

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Indeed endocannabinoid signaling through CB1R regulates the activity of dopamine (DA) neurons in the VTA [52], which projects to the nucleus accumbens, a key brain reward region activated by addictive drugs including THC [53, 54]

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