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Two people can have the same BMI but drastically different future health risks

Hormonal Regulation of Appetite and Metabolism in Women

"The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions." Lancet Diabetes Endocrinol

doi: 10.1093/ajcn/83.1.89
While GLP-1 degradation is unaffected by kidney function, the clearance of both GLP-1, and to a greater extent its inactive metabolites, is delayed in patients with renal insufficiency [184]

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