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Ann Dermatol 2017;29:205

While liraglutide improved spatial cognition, it also reduced astrocytes and microglia activity, ameliorated amount of A levels and mitochondrial dysfunction in cortical and hippocampal CA1 and CA3 regions, and prevented neuron loss by activating cAMP/PKA pathway in brain of 5FAD mice (188, 208)

Areas including the hypothalamic ARC and the area postrema containing GLP-1RA but lacking a blood brain barrier may respond to direct stimulation from more potent GLP-1RAs

Theyre expensive (were talking $1,000+ a month without insurance), can cause side effects (hello, nausea), and require long-term use to keep the weight off

The traditional classification of DM is mainly based on abnormalities in insulin secretion and action, such as type 1 DM due to an absolute lack of insulin secretion and T2DM due to insulin resistance and relative insulin deficiency