repurposing semaglutide and liraglutide for alcohol use disorder A new clinical trial supported by the National Institutes of Health (NIH) found that a medication commonly used weight loss, such as semaglutide, may also help reduce heavy drinking in individuals GLP-1s Could Help Reduce Alcohol
Description
Study Design: 203 obese patients (BMI 3040 kg/m) Randomized to tesofensine 0.25 mg, 0.5 mg, 1.0 mg, or placebo All groups received dietary counseling (mild energy restriction) Primary endpoint: change in body weight at 24 weeks Registered as NCT00394667 Key Results: The 0.5 mg dose produced 10.6% placebo-subtracted weight loss roughly double what existing anti-obesity drugs (sibutramine, orlistat) achieved at the time
plantarum reduced the abundance of Bacteroides and Parabacteroides , and also decreased the levels of lithocholic acid (LCA), eventually increasing BG (104)
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