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The interaction of ox-LDL with CD36 triggers a signaling cascade that is necessary for ox-LDL uptake and foam cell formation and that alters cytoskeletal dynamics and inhibits migration, thus contributing to the trapping of foam cells within the atherosclerotic plaque [59]

And how about for Rybelsus, even though it only hits one target

While the pharmacological GLP1R agonist semaglutide primarily activates GLP1R signaling in the pancreas, GLP1R is also expressed in advanced prostate cancer where GLP1R agonism could directly alter cellular signaling

GLP-1 Increases Preingestive Satiation via Hypothalamic Circuits in Mice and Humans

M.ShinH.HansenT

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