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These gastrointestinal effects typically diminish over the first few weeks of treatment as tolerance develops
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For senescence of VSMCs, GLP-1RAs activate Nrf2 and inhibit Rac1 through cAMP/PKA pathways to prevent Ag II-induced senescence [122, 123]

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Three-year data from 5 HARMONY phase 3 clinical trials of albiglutide in type 2 diabetes mellitus: Long-term efficacy with or without rescue therapy
