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Pyke C, Heller RS, Kirk RK et al (2014) GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody

(A) GLP-1 can induce fibronectin type III domain-containing protein 5 (FNDC5) expression in pancreatic -cells through the interaction of its downstream transcription factor cAMP-response element binding protein (CREB) with binding elements in the FNDC5 promoter, thereby promoting the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT)

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Mechanism: GLP-1s can lower blood pressure, improve cholesterol levels, and reduce inflammation in the blood vessels, all of which contribute to their cardioprotective effects

German AJ, Maddison JE, Guilford G

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