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Regarding lipid metabolism, the promotion of PUFA incorporation into membrane phospholipids, a process catalyzed by ACSL4, provides the essential biochemical fuel for ferroptosis (242)

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Estrogen also influences GLP-1 receptor sensitivity

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However, clinical outcomes are complicated by behavioral factors, including lower adherence rates reported among women, which may obscure the true extent of sex-related efficacy differences [52]

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