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What is the significance of the incretin effect

Patients are randomized to 2.5 to 5 years of weekly semaglutide injections or placebo as an adjunct to standard care

The clinical trial evidence does not support a meaningful risk of C-cell stimulation in humans taking tirzepatide

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doi: 10.1016/j.carbpol.2021.118231

The core machinery of this axis is the IP3R-GRP75-VDAC1 tripartite complex, where GRP75 (Szabadkai et al., 2006) acts as a linker protein that physically bridges the IP3R on the ER (Bartok et al., 2019) to the VDAC1 channel on the mitochondria (Rapizzi et al., 2002), funneling ions directly into the mitochondrial matrix (Szabadkai et al., 2006)