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None of these has a direct interaction with semaglutide

Unexpected pregnancies on tirzepatide have been reported, often attributed to improved fertility from weight loss

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Gallbladder issues, including gallstones, may occur, especially during rapid weight loss

Given that cessation of treatment often leads to significant weight regain, there are concerns that older adults may be at risk for sarcopenic obesity

The overaccumulation of triacylglycerol and cholesterol in the hepatocytes and the overproduction of reactive oxygen species (ROS) both lead to local inflammatory responses
