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Discussion Obesity is a substantial clinical and economic burden 1 that has grown rapidly in recent decades 45 and is expected to continue to increase globally in the coming years

In the STEP 1 trial, dual-energy X-ray absorptiometry (DXA) substudies showed that semaglutide treatment resulted in a greater proportional decrease in fat mass compared to lean body mass over 68 weeks, though absolute lean mass reductions were observed alongside the predominant fat loss

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Your provider will determine whether semaglutide, tirzepatide, or another approach is most appropriate based on your health history, goals, and individual response to treatment

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