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All these emerging benefits have made GLP-1 RAs an important pharmacological drug

Manage constipation proactively Do not wait for constipation to become a problem

use alternative contraceptive methods during treatment initiation and for 4 weeks after each dose escalation Concomitant medications: Avoid coadministration with other GLP-1 receptor agonists for weight management Patients should be advised to seek medical attention for: Severe, persistent abdominal pain that may radiate to the back (potential pancreatitis) Signs of thyroid tumors including neck mass, dysphagia, dyspnea, or persistent hoarseness Symptoms of acute gallbladder disease (right upper quadrant pain, fever, jaundice) Severe gastrointestinal symptoms leading to dehydration Changes in vision or signs of hypoglycemia Signs of hypersensitivity reactions including rash, itching, or difficulty breathing Clinicians should conduct a thorough medical history before initiating tirzepatide, including assessment for personal or family history of medullary thyroid carcinoma or MEN 2, history of pancreatitis, severe gastrointestinal disease, and diabetic retinopathy

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He set up the first reference library to offer insulin assays to NHS hospitals through the UK (Illman

Perkovic V et al