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Clinical trials show Contrave produces average weight loss of 5-9% of baseline body weight over one year

A study on a mouse model of pulmonary fibrosis showed that GLP-1RA could reduce the expression of collagen and hydroxyproline and inhibit the enzymes involved in IPF formation, besides having a positive effect on surfactant production and inhibiting the activity of inflammatory cells and cytokines [84]

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All 22 participants had previously been treated with a GLP-1 therapy for durations ranging from approximately 5 months to 5 years, with a mean total body weight loss of 24% while on therapy and a mean body weight of 80 kg 3 kg (SEM) at the time of intervention

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One of the most promising aspects of GLP-1 agonists potential cognitive impact is their apparent ability to modulate inflammation