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glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP‑1 Depression: Can These Drugs
Description
The GLP-1 receptor agonist market is experiencing significant growth, driven by the increasing prevalence of type 2 diabetes and obesity, and the high...
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://www.diabetesincontrol.com/wp-content/uploads/2026/01/glp1-depression-brain-therapy-concept.png)
Drugmaker Eli Lilly announced the FDA approved its oral GLP-1 pill, called Foundayo.
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://www.thelancet.com/cms/10.1016/S2215-0366(26)00014-3/asset/40e31193-0789-44ef-bfbd-d626246a3086/main.assets/gr4_lrg.jpg)
Retatrutide, a new weight-loss drug, helped people lose 30% of their body weight in a study, rivaling results seen with weight-loss surgery.
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://www.frontiersin.org/api/ipx/w=1200&f=png/https://www.frontiersin.org/files/Articles/721135/fendo-12-721135-HTML/image_m/fendo-12-721135-g001.jpg)
Many people living with Multiple sclerosis are already...
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://cdn.sanity.io/images/0vv8moc6/psychtimes/bdd993c6eb36d370bb0dc5873bf98998844664f8-1362x544.png/McIntyre%20Figure.png?w=1362&max-h=544&fit=crop&auto=format)
At 12 months, weight loss persisted at around 4%, with variability between agents, most notably liraglutide
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://cdn.prod.website-files.com/67eb320892c08516077ad204/6911e545acb06a90f528edfb_rgeJLt5rF8gpNkyk9gEYulcLjSCV7XU-x7vLIP4QgK0.png)
HbA1c and weight cohorts were analysed separately using an ANCOVA model
![glp-1 agonist depression Agonists Can Be Heaven or Hell Dependent Upon Dopaminergic Genetic/Epigenetic Antecedents[v1] GLP1 Depression: Can These Drugs](https://www.jneurosci.org/content/jneuro/45/46/e1375252025/F1.large.jpg?download=true)
