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Local vaginal estrogen is often used because it acts directly on vaginal estrogen receptors, helping restore tissue thickness, elasticity, moisture, and microbial balance with limited systemic absorption

Nausea affects 20% to 33% of participants across clinical trials

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Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K

The GLP-1 receptor system directly influences reward pathways in the brain, and tirzepatide modulation of these pathways changes how your brain responds to food cues
