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One study from 2013 followed 154 people with obesity or overweight who took metformin for six months

Also increase your water intake throughout the day because fiber without adequate water makes constipation worse

The contradictory findings may reflect differences in comparison groups (comparing to no treatment versus comparing to another diabetes medication), patient populations, or unmeasured confounding variables

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Each option differs in dosing, evidence, and suitability

If you've just started semaglutide or tirzepatide, hydration probably wasn't the first thing on your mind but in our practice, it's one of the most common reasons people feel unwell in the first few weeks