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Wegovy, which contains semaglutide, is not known to commonly cause muscle cramps, but some people report experiencing leg cramps during treatment, especially while losing weight
These results suggest that Phe 12 and Thr 13 play a more important role in stabilizing the N-capped conformation via intramolecular interactions within GLP-1 and/or in stabilizing the activated conformation of GLP-1R via intermolecular interactions with the receptor
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It may not be the ideal first choice for someone who is highly medication-sensitive or primarily wants a very gentle introduction to GLP-1 therapy

Unused Ozempic pens may be used until the expiration date (EXP) printed on the label, if kept in the refrigerator

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