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As a dual agonist, tirzepatide (GLP-1 + GIP) continues to outperform semaglutide in weight loss and metabolic control, setting a new bar for combination therapies

This finding is biologically plausible

Many large employer plans in Texas have excluded weight loss medications entirely, though some have begun adding coverage in response to employee demand

Pharmacological determinants in GLP-1RA-Associated cancer risk Differential cancer risk profiles across GLP-1RA subtypes and dosing regimens Existing studies underscore significant differences in the effect of various GLP-1RAs on the risk of specific cancers, such as pancreatic cancer [6,7,8, 26, 27]

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