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The specific reasons identified include intensive insulin therapy, decreased renal function, severe liver disease, alcohol ingestion, defective counter regulatory hormone release, missing meals/fasting, and gastroparesis

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[DOI] [PubMed] [Google Scholar] 9.Liberati A, Altman DG, Tetzlaff J, et al

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More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1." Mouse Studies Confirm GLP-1 Resistance The findings were so unexpected that the researchers spent several years testing whether the result was real