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For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg
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The intermediates from de novo lipogenesis in the liver will disrupt mitochondrial function and produce ROS, and then cause endoplasmic reticulum (ER) stress, ultimately leading to inflammation, and the broken cells releasing cytokines will cause more cell death ( The excess free fatty acids (FFAs) and de novo lipogenesis would break the homeostasis of lipid metabolism
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Your provider shows up as a cartoon icon with their name, which feels impersonal, if Im honest

MAFLD : how is it different from NAFLD
