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GLP-1s) due to lower energy intake and weight loss without lowering the weight (fat) setpoint (body fat level defended by the body)

Lobato CB, et al

It also lowers glucagon secretion, slows stomach emptying, promotes satiety, and improves glucose disposal in peripheral tissues

In recent years, some of these drugs have also been approved to treat obesity and for weight loss

That distinction matters enormously for semaglutide users, because S

The number of patients at the 4-milligram dose who discontinued treatment due to side effects was lower than the placebo group, which Skovronsky called "remarkable to see." Around 4% of patients on that dose stopped the drug due to side effects, compared with nearly 5% with the placebo