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Overall, the benefit-risk profile supports broad use of GLP-1-based therapies in MASLD across most patient subgroups, with individualized monitoring plans for high-risk populations

[DOI] [PMC free article] [PubMed] [Google Scholar] 284.Liu Z, Zhang Y, Liu J, Yin F

Glp1r / mice 40 were crossed with Glp2r / mice to generate Glp1r +/ Glp2r +/ , then bred to generate Glp1r / Glp2r / and wild-type controls

Demand for GLP-1 improves the capacity utilisation of fill-finish capabilities offered by CDMOs While GLP-1 manufacturers are investing significantly in the development of the drug, few have the capacity to complete filling and packaging in-house

K., Louhivuori, L

Exenatide was also safe and well-tolerated, with no patients in the exenatide-treated group withdrawn due to excessive weight loss and weight loss reversed following drug cessation, within the latest trial [87]