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The mice were housed at a constant temperature and humidity under a 12-h/12-h lightdark cycle with free access to standard food and water for at least 1 week prior to the beginning of the experimental procedures

doi: 10.1056/NEJMoa1612917 [DOI] [PMC free article] [PubMed] [Google Scholar] 18.Buse JB, Rosenstock J, Sesti G, et al

[DOI] [PubMed] [Google Scholar] 80.Diamant M, Van Gaal L, Stranks S, Northrup J, Cao D, Taylor K, et al

If these lifestyle changes do not provide relief, consult your healthcare provider about whether a mild over-the-counter stool softener is appropriate for you

The presence of this side effect did not impact the drug's effectiveness, however

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